Aiming to address the issue of lateral tipping instability that high-clearance sprayers are prone to roll when subjected to road excitations, an integrated control strategy for maneuvering stability was proposed based on additional active steering. An eight-degree-of-freedom vehicle dynamics model, incorporating a high-precision magic formula tire model, was established to accurately describe the vehicle's nonlinear dynamic characteristics. Based on sliding mode variable structure control theory, a two-layer lateral stability controller was designed: the upper controller was the vehicle body attitude sliding mode controller, responsible for calculating the additional generalized torque required to maintain vehicle body stability;the lower controller was the electro-hydraulic position servo sliding mode controller, which precisely executed the steering adjustment commands given by the upper controller. A test platform for sprayer lateral stability control was constructed to verify the effectiveness of the controller. Test results showed that under step steering conditions, the absolute mean errors of yaw rate, roll angle, and centroid lateral deviation angle were decreased by 15.7%, 9.3%, and 35.0%, respectively;under sinusoidal conditions, the absolute mean errors of yaw rate, roll angle, and centroid lateral deviation angle were decreased by 17.8%, 8.6%, and 25.0%, respectively. The results validated that the designed active steering strategy effectively improved the lateral stability of the sprayer. This fully demonstrated the effectiveness of the control strategy in suppressing vehicle body roll and maintaining the driving path, providing a valuable solution for improving the active safety performance of high-clearance sprayers under low-speed complex conditions.