Aiming to address the prevalent issues of high daytime temperature and high nighttime humidity in solar greenhouse cherry production, a mixed-ventilation strategy was developed and validated based on forced convection to optimize the indoor thermal-humidity environment and enhance fruit quality. Taking typical solar greenhouses in Yulin (planted with cultivars ‘Brooks’, ‘Summit’, and ‘Rainier’) as the research object, computational fluid dynamics (CFD) simulations and environmental monitoring were firstly employed to compare the effects of natural ventilation and different forced convection modes (rear-wall fans blowing downwards/upwards) on the temperature, humidity, and airflow fields, thereby determining the optimal ventilation scheme. Subsequently, field comparison experiments were conducted to verify the practical effectiveness of the optimized strategy on environmental regulation and its impact on fruit quality during the fruiting stage. Both CFD simulations and field measurements indicated that the mixed-ventilation strategy with “rear-wall fans blowing downwards” performed optimally. Compared with natural ventilation, this strategy effectively reduced the daytime canopy temperature (max. reduction of 3.9℃) and significantly suppressed high nighttime humidity (maximum reduction of 14.6 percentage points in the plant zone) while avoiding excessive cooling. Quality assessments revealed that this strategy significantly improved the commercial and nutritional value of the fruit: for ‘Brooks’, single fruit weight was increased by 19.8% and firmness by 31.6%; for 'Summit', the a? value (redness) and total phenolic content were increased by 26.9% and 36.1%, respectively; the edible rate and total soluble solids of ‘Rainier’ were also significantly enhanced. The sugar-acid ratio was significantly improved across all cultivars. The proposed mixed-ventilation strategy effectively overcame the environmental bottlenecks in solar greenhouse cherry production. It represented an efficient, low-cost environmental control technology for achieving high yield and quality, providing an engineering basis and practical solution for precision climate control in protected horticulture.