Considering the intelligent development trend of manufacturing industry in current and the key role of CNC machine tool in modern manufacturing engineering, a multi-objective optimum seeking method of CNC machine tool is proposed, which combines the advantages of quality function deployment (QFD), fuzzy linear regression, and zero-one goal programming (ZOGP). On the basis of studying intelligent manufacturing’s specific requirements, QFD is utilized for examining the causal relationships between intelligent manufacturing’s requirements and CNC machine tool’s performances. The intelligent manufacturing’s requirements are incorporated into machine tool selection by house of quality (HOQ). Fuzzy linear regression is used to determine the extent of functional relationships between intelligent manufacturing’s requirements and machine tool’s performances in the HOQ. The weight coefficients of CNC intelligent manufacturing’s requirements indexes are calculated by analytic hierarchy process (AHP). Zero-one goal programming is used to select the optimal CNC machine tool. Taking the CNC machine tool’s multi-objective decision problem in constructing an intelligent manufacturing platform as application case, and the optimal one with high comprehensive performance is selected from five alternative CNC machine tools. The study result shows that the proposed multi-objective optimum seeking method of intelligent manufacturing oriented CNC machine tool has high practicability.