Optimization of regional ecological security pattern is the basis of regional ecological security. It is of great significance to analyze and optimize the regional ecological security pattern by using proper models and methods. The optimization of regional ecological security pattern requires the integration of multi-disciplinary synthesis, multi-perspective analysis and the combination of various means. It is generally based on the understanding of the relationship between different landscape types, landscape spatial pattern, landscape process and function. Typically, the impact ways of landscape pattern on the process are found first. Then, a mathematical model is built based on the principles of landscape ecology to optimize land use and local ecological security pattern from multi-level, multi-perspective and multi-disciplinary views. Based on the analysis of domestic and foreign research progress, a summary of the concept development, the evolution of the research content and the optimization methods of regional ecological security pattern was made. And the future research trend of regional ecological security pattern was obtained, including organic integration of multi model, multi method and multi technology, quantitative exploration of regional ecological security standards, public participation mechanism and management methods of interest coordination.