With the wide application of microchannel heat exchanger, more and more researches focus on the microchannels and the pressure drop characteristics are important research object. Pure refrigerant R141b was used as working fluid in microchannels to carry out boiling flow experiments and explore the effect of surface energy on flow boiling pressure drop characteristics. Fluoroalkylsilane solution in different concentrations was used to modify the surface energy of different microchannel tests with size of 2.0mm×1.0mm, and tests were obtained with different surfaces energy. The flow boiling pressure drop characteristics were experimentally investigated through the tests by using R141b refrigerant. The influence of surface energy on pressure drop were investigated, and then a modified model was got. The results showed that the surface energy of tests were low with long immersion time and high concentration, and the tests with low surface energy had big numerical value of frictional pressure drop. The twophase frictional pressure drop was increased by 5.1% and 12.7%, respectively. The predicted values of different correlated models were compared with experiment values, and a modified model which had a better predicted result was obtained, the mean absolute error was decreased obviously. The result provided supplement for the research on flow boiling resistance characteristics.