Traditional irrigation practices caused low maize water use efficiency, yield and income of local farmers in Nile Delta of Egypt. To explore the optimal irrigation and fertilization strategies, the effects of interactions between irrigation and fertilization on leaf area index (LAI), aboveground dry matter (ADM), yield component, water use efficiency (WUE), economic yield and benefit of maize were investigated. During the field experiments in two consecutive years (2012 and 2013), there were three irrigation modes (drip irrigation, bubble irrigation and traditional furrow irrigation, irrigation rates were 80%, 70% of estimated evapotranspiration and local traditional irrigation quantity, respectively) and two fertilization types (liquid organic fertilizer and chemical fertilizer). Six treatments were arranged in a randomized complete block design, with four replicates for each treatment. The results showed that irrigation modes and fertilization types had significant effects on the LAI and ADM after the tasseling stage, with the largest LAI and ADM in the treatment applied liquid organic fertilizer with drip irrigation (OD). For the same fertilization type, bubble irrigation had higher impact on maize yield and WUE than drip irrigation, and then followed by traditional furrow irrigation. For three irrigation modes, liquid organic fertilizer increased maize yield by 18.6%～24.4% and WUE by 18.7%～23.4% compared with chemical fertilizer. The treatment applied chemical fertilizer with bubble irrigation (CB) yielded the highest average annual net benefit of 7 373 Yuan/hm2, but there was no significant difference between the treatments of CB and CF (applied chemical fertilizer with traditional furrow irrigation). In general, the combination of bubble irrigation and chemical fertilizer can be recommended as the optimal irrigation and fertilization strategy for maize production in Nile Delta, which will have a broad prospect for field irrigation in Egypt.