In order to improve the accuracy of parameters required in the discrete element compression moulding simulation process of corn straw and cow manure blends, a parameter calibration test on corn straw-cow manure mixtures was carried out and the accuracy of the calibrated parameters was verified by using a combination of simulation analysis and physical tests. The parameters with significant influence on the discrete elements of the blends were screened out through the screening test;taking the stacking angle as the evaluation index, the Design-Expert software was used to carry out the steepestclimbing experimental design and the Box-Behnken experimental design for the three parameters with significant influence, and the particle swarm optimisation (PSO) algorithm was applied for the parameter optimization, and the optimal parameter combinations were obtained as follows: corn straw-cow manure rolling friction coefficient was 0.128, cow manure-cow manure rolling friction coefficient was 0.320, and cow manure-cow manure JKR surface energy was 0.033J/m2;the simulation test was conducted under the conditions of this parameter combination, and the results showed that the relative error between the simulated stacking angle and the actual stacking angle was 1.27%, and the relative error between the uniaxial compression simulation test and the maximum compression displacement in the physical test was 2.97%. The results can provide a reference for the discrete element simulation of compression moulding of corn straw-cow manure mixture.