In order to improve the performance of differential pumps, a sixblade differential pump driven by denatured higher order ratio Fourier non-circular gear pairs was proposed. The denatured Fourier non-circular gear transmission model and the performance calculation model of the six blade differential pump were established, and the differential pump performance analysis software was compiled. The differential pump displacement, flow rate and pulsation rate were calculated at different order ratios and different denaturalization coefficients. The results showed that high order ratio was beneficial to improving the performance of sixblade differential pump, and the change of denaturation coefficient was beneficial to reducing the pulsation rate of single pump. The performance of the sixblade differential pump proposed was better than that driven by the ordinary Fourier noncircular gear pairs. In the same pump shell size and pipeline environment, the micro-strain of input shaft of the first impeller of single pump was reduced by 35.2%. It was indicated that the pulsation rate of differential pump would be decreased. The maximum modulus was increased by 27.7%, the displacement of the differential pump was reduced by 1.2%. The design was more conducive to low pulsation and large load conditions.