In order to discuss the feasibility of DSSAT model in the optimization of irrigation schedule for winter wheat in different hydrological years, the corresponding design values of precipitation experience frequency of 25%, 50% and 75% were obtained by using the precipitation data of the growth period of winter wheat from 1985 to 2015 in Lianshui Water Conservancy Research Institute. After that the years from 2001 to 2016 in Huaian Station with close corresponding precipitation of three kinds of empirical frequencies were taken as the representative years, and that was 2007—2008 (wet year), 2006—2007 (normal year) and 2011—2012 (dry year). Fifteen irrigation schedules（T1～T15） were drawn up through different combinations of growth stages and irrigation times, and the irrigation schedules were simulated in three hydrological years by using the DSSAT model after the parameter estimation and verification. The results showed that after calibrated, the genetic coefficients of winter wheat could accurately reflect the main genetic characteristics. Considering the yield, irrigation water capacity and the water use efficiency of winter wheat as a whole, it was advisable to select the irrigation schedule T3 from 2007 to 2008 (wet year), from 2006 to 2007 (normal year), and from 2011 to 2012 (dry year). The schedule T3 was irrigated with 50mm in the regreening period. The irrigation time of wintering, regreening and jointing periods were on December 25, February 20 and March 30, respectively. Under BCC-CSM1.1 climate model, RCP45 and RCP85 were considered to simulate the water and yield effect of winter wheat in 2030—2095 years, and then it was found that when the initial soil moisture content was 60% and 80% of the field capacity, T3 and T6 both had certain feasibility compared with the rainfed conditions.