According to the complexity of traditional hydraulic performance optimization design of centrifugal pump, the hybrid surrogate model method which is the combination of proper orthogonal decomposition and radial basis function was proposed for the flow reconstitution of centrifugal pump impeller. The blade of low specific speed centrifugal pump was parameterized by cubic Bezier curve, and the experiment samples can be designed by introducing small perturbation of control parameters which included wrap angle, inlet and outlet blade angles. The snapshot set consisted of the control parameter for blade shape and the flow field data. According to the geometric similarity of the impeller flow passage and the mesh deformation technology, the flow field data of the similar position were interpolated. The snapshot set can be decomposed as linear combination of orthogonal basis by using proper orthogonal decomposition. The orthogonal basis coefficients for the objective blade were fitted by using radial basis function. The flow field data of the objective impeller were reconstructed. In the calculation case for the type of MH48-12.5 centrifugal pump, the flow field in impeller was reconstructed. The root-mean-square error for pressure prediction was 0.84%, and the velocity prediction error was within 0.5m/s. The computation time for the flow field prediction was less than 1/240 of the CFD. POD base modal analysis was carried out on the sample set. The base modal characteristic of flow field and its energy distribution were analyzed.