Based on the former research on heat pump drying characteristics of wolfberry, a large heat pump drying room was designed and established, and then 1000kg of wolfberry fruit was dried. The result showed that the heat pump drying room could supply abundant heat and control temperature and humidity precisely, which could meet the needs of wolfberry drying process. During the drying process, the temperature was gradually increased and humidity was decreased, it was reasonable to set 10 as a turning point at the drying stage, namely the moisture content could be detected when temperature was risen to 52℃, if the moisture content on dry basis was higher than 1.0, the set temperature should be maintained, if the moisture content was arrived at or below 1.0, the temperature could continue to be risen, the highest temperature was not higher than 64℃. The quality of dried wolfberry in different positions of heat pump drying room was measured, which showed that the total phenol content was between (5.92 ± 0.3)mg/g and (8.12 ± 0.18)mg/g, the total ketone content was between (70.99 ± 1.68)mg/g 〖JP3〗and (113.88 ± 0.26)mg/g, the total phenol content and total ketone content of the samples in the back of the room were significantly higher than those in the front. From the point of antioxidant properties, samples in the back of the room had higher ·DPPH scavenging activity and ferric ion reducing antioxidant power than those in the front. Compared with the wolfberry dried in the coal chamber, samples dried by heat pump drying room had higher overall quality (total phenol, total ketone. ·DPPH clearance, iron ion reduction ability), and the drying time was reduced by 20% and drying costs was reduced by 19%, hence heat pump drying process was reasonable and heat pump drying room could be applied to production practice.