Taking “Zhongza 105” tomato as tested material, the experiment focused on the effect of different CO2 enrichment concentrations and different nutrient supply intensities on the growth of tomato cultivated in substrate in solar greenhouse. This study set up 4 CO2 levels, including no enrichment (C0), (700±50)μmol/mol (C1), (1000±50) μmol/mol (C2), (1300±50)μmol/mol (C3) and 3 nutrient levels based on a dose (S) of Yamazaki tomato recipe nutrient solution concentration, including 1/2S (F1), 1S (F2), 2S (F3). The results indicated that stem diameter, SPAD value of leaves, fresh and dry weight of plants, nitrogen content of leaves and weight of the first spike fruit were increased significantly with increasing nutrient quantity at the same CO2 level, and blooming date was advanced. CO2 enrichment increased stem diameter, SPAD value of leaves, fresh and dry weight of plants and weight of the first spike fruit, but reduced the position of the first inflorescence and made blooming date ahead of time at the same nutrient. When the concentration of CO2 enrichment was (1000±50)μmol/mol or (1300±50)μmol/mol, the nitrogen content of leaves was elevated. The promoting effect of CO2 enrichment on the growth of tomato was associated with nutrient quantity, under low and moderate nutrient conditions, CO2 enrichment at (1000±50) μmol/mol was adequate for reducing the position of the first inflorescence of 1.0 compared with the control (C0F1 or C0F2), advancing the florescence for 5~8d and increasing the weight of the first spike fruit significantly. Under high nutrient condition, CO2 enrichment at (1300±50)μmol/mol made the position of the first inflorescence lowest, 1.7 lower than the control (C0F3), the florescence was the earliest, which was 10d earlier than the control, and the weight of the first spike fruit was the maximum, 24.15% higher than the control. The response of position of the first inflorescence, florescence and weight of the first spike fruit to CO2 enrichment depended strongly on the level of nutrient supply. High nutrient level improved the response of these indexes to CO2 enrichment. According to the entire growth index, C3F3 was the best combination of CO2 and nutrient, its stem diameter and weight of the first spike fruit were the maximum, position of the first inflorescence was the lowest and blooming date was the earliest.