Aerial spraying may easily lead to loss of droplets with the wind from crosswinds and influence of spray effect. This article analyzes related factors which influence spray drift behavior, and sets up the motion equations of the droplet in three-dimensional coordinate system. A prediction model of droplet drift under crosswind condition is received so that the droplet drift distance can be predicted by calculating. Spray drift experiments are done under different flow and spray conditions by using wind tunnel with the droplet concentration testing method. Actual droplet drift distance in the wind tunnel conditions are obtained through simulation of the linear regression method. Experimental results show that as the air velocity increases, spray drift distance increases significantly, and droplets with diameters less than 200 μm under crosswind are more prone to drift. For the large droplets with diameters bigger than 250 μm, although the drift along downwind direction of the wind tunnel still happen, the drift distance is shorter since the kinetic energy of the vertical direction is relatively larger. Through analyzing and comparing droplet drift distance from prediction model with the results of calculating and estimates, it is observed that the results meet the requirements. It is concluded that the motion model of droplet as the dominant expression of spray drift behavior is feasible.