Dolphin’s special mosaic skin structure has characteristic of drag reduction. Imitating this special structures, a kind of bionic coupling functional surface was designed. Two-way fluid-solid coupling simulation was carried out on the mosaic bionic coupling functional surface using ANSYS-Workbench software, while the fluid calculation used the standard turbulence model, and the solid calculation used transient structural. The simulation result showed that the turbulent kinetic energy and the surface speed of the coupling functional surface were significantly reduced, and the flexible material produced displacement deformation. The above simulation result indicated, that the flexible material of surface coupled with non-smooth structures of substrate through conforming fluid medium to achieve the control purpose. The elastic deformation of surface material absorbed part of energy, and effectively reduced the turbulent kinetic energy of the fluid medium, to avoid the energy loss caused by excessive exchange between the fluid-solid interface.