ISD suspension has been widely studied by scholars，while semi-active control study on three components ISD suspension is still unsatisfactory. To study the influence of ISD semi-active suspension on automobile comfort and safety, a 2-DOF dynamic model for automobile ISD semi-active suspension was established. Simulation analysis adopted fuzzy control method with body vertical velocity and vertical acceleration signals as the fuzzy controller input was carried out on the suspension system. On this basis, a fuzzy control system for this suspension system was developed and designed by dSPACE, and its bench test was performed. The responses of ISD semi-active suspension to random road input at different velocity were analyzed. Simulation results were in agreement with experimental results. The results show that the mathematical model of ISD semi-active suspension is correct, and the ISD semi-active suspension with fuzzy control is superior to ISD suspension in damping suspension vibration as well as in improving vehicle running smoothness.