The total sugar, starch and reducing sugar, yield and pH value change were thoroughly studied in solid state fermentation for protein feed production from Panax notoginseng residues. The related degradation kinetic model of total sugar and starch was established as well. The results showed a four-parameter model matched well the degradation kinetics of total sugar and starch and predicted the change of total sugar and starch contents relatively accurately. The half-life of total sugar and starch were determined as 58.32h and 42.47h, respectively. The peaks of degradation rate were observed at 46.1h and 29.1h, respectively. The average degradation rates of both total sugar and starch in the fast degradation stage were twice more than those in the slow degradation stage. It was found that the average degradation rate of starch was greater than that of total sugar in the fast degradation stage, but oppositely less in the slow degradation stage.