Nine sieve matrixes with different sizes and spacing of bionic micro surface-rebuild was fabricated by YAG—M50 laser-marking machine. Surface profile of the samples was analyzed by NT1100 optical profiling system. Double-distilled water and rapeseed oil were chosen as liquid component, with which contact angle of the nine sieve matrixes was obtained by CAM101 contact angle meter. Wettability of the bionic sieve matrix was analyzed with factors of figure size and spacing. The results showed that the spacing between two figures had significant influence on wettability when the figure size was small, while the influence of figure size on wettability was related to the liquid component with the same spacing condition.