0.35%和0.944%。A new optimization method based on genetic algorithm for the optimization of a centrifugal blade profile was presented. Different from the traditional optimization method, the hydraulic performance of centrifugal blade profile was predicted with CFD technology in the new developed method. The hydraulic efficiency and theoretical head were defined as the objective functions for the blade profile optimization using multiobjective genetic algorithm. Three key technologies were employed as the follows: 3-D blade profile parameterization, grid generation & CFD analysis, multiobjective optimization. By this optimization method, a single-stage single-suction centrifugal blade was redesigned and optimized at the design condition. The results showed that the objective function values of the maximum hydraulic efficiency and the theoretical head were increased by 0.35% and 0.944% respectively. 