The high concentration of salt inhibits the growth of microalgae in wastewater. Indole-3-acetic acid (IAA) was added to promote the growth of microalgae under salt stress. At the same time, the effects of different algae species and salt ion on the growth, nitrogen and phosphorus removal of microalgae cultured in high-salt wastewater were investigated. The results showed that the maximum biomass of Chlorella vulgaris, Desmodesmus sp. and Scenedesmus quadricauda could reach 0.55g/L, 0.66g/L and 0.75g/L under the flow-feeding mode. The maximum specific growth rates of Desmodesmus sp.and Scenedesmus quadricauda were 0.18d-1 and 0.17d-1 on the 4th day, while Chlorella vulgaris were 0.14d-1 on the 8th day. The removal rates of TN and NH+4 N were 70.7%, 88.5%, 79.7% and 90.7%, 92.6%, 92.4%, respectively. The removal rates of TP were more than 90%. The growth of Scenedesmus quadricauda in the high-concentration IAA (20 mg/L) was the best, and the biomass was up to 0.403g/L. The growth of Scenedesmus quadricauda in the low-concentration IAA (≤2mg/L) was not significantly promoted or even inhibited. The removal rates of TN and NH+4 N were 20% and 44.1% in 20mg/L IAA, respectively. The TP removal rate was 97.2% in 20mg/L IAA, and the other five groups were maintained at about 15%. In addition, the biomass under different salt conditions was 0.667g/L (blank group), 0.750g/L (Cl-group), 0.898g/L (NH+4 group) and 1.037g/L (NH+4+Cl-group), respectively. There was no significant difference in the removal efficiency of N and P among all groups. The removal rates of TN and NH+4N was about 30% and 50%, and TP was more than 90%. The above studies indicated that high concentration of IAA could significantly promote the growth of Scenedesmus quadricauda under salt stress, and the biomass was the highest in mixed group (NH+4+Cl-). Therefore, the research result can provide data support for the subsequent application of microalgae in the treatment of high-salt wastewater.