The strike of blades is the most important factor for the damage to fish passing through the pump. In order to study the strike damage characteristics of fish passing through the tubular pump, based on the CFD-DEM coupling method, the drag force calculation model was optimized by modifying the coupling interface to study the movement behavior and force damage of the fish after striking with the blade and wall of the tubular pump. Taking the simplified plate strike on fish as the starting point of numerical simulation, the influencing factors of strike damage caused by the collision between fish body and blade were analyzed, and the death caused by over-pump damage of fish body was predicted. The results showed that the strike damage caused by fish body collision was related to the strike force on fish body. Increasing the front edge thickness, reducing the front edge inclination angle, and reducing the strike speed can reduce the strike force between the fish body and the blade leading edge to reduce the stress damage of the fish body. It was reasonable to obtain the impact force threshold of 2446N that led to the death of L/d=2 fish; increasing the front edge thickness, reducing the front edge inclination angle, and reducing the strike speed can reduce the collision force between fish body and leading edge of blade, thereby reducing the impact damage of fish; the strike force between fish and leading edge of the blade of pump was the largest, and its strike damage was the most severe, which meant that the leading edge of blade of pump was the main part responsible for fish death in the tubular pump device; the smaller the size of fish body in the inlet flow of pump station was, the lower the probability of blade strike was; reducing the ratio L/d of the length of fish body to thickness of leading edge of the blade could reduce the strike force of leading edge, thereby improving the survival rate of fish passing through the pump.