In order to solve the problem of low collection success rate caused by the attachment of tea leaves to the wall during selective picking of famous tea, a tea harvester was designed according to the physical parameters of one bud and two leaves. The factors that affecting the success rate of tea collection were obtained through pretest: the negative pressure value, the number of thread lines and the parameter variation range of thread lead. Fluent simulation and Box-Behnken response surface analysis were used to study the interactive influence of various factors on the success rate of tea collection. The experimental results showed that three factors changed the tangential velocity of air near the wall in the pipe;in the order of significance, the influence of each factor on the success rate of collection was negative pressure value, thread lead and thread number;taking the success rate of tea collection as the optimization goal, the parameters were optimized and rounded, and the parameters were obtained as follows: negative pressure value H=120Pa, thread number N=9, thread lead S=95mm. The optimized parameters were used to carry out adsorption collection test, the results showed that the success rate of tea collection under this condition was 98%, that was, the success rate of tea collection after optimization was 26 percentage points higher than that before optimization, and the relative error between the experimental value and the predicted value was less than 5%, so the optimization model was reliable.