To solve the problem of grass-soil non-separation leading to weeds regrowth and debris fly-shot when the weeding machine is working in hilly mountainous areas, a weeding machine which separated weeds and soil with combination of throwing and pushing was designed. The weeding wheel with symmetrical spiral structure pushed the soil to both sides at low speed to avoid flying debris. The knife teeth threw the weeds backward to achieve weed-soil separation and prevented the resurgence of weeds. The shape and number of the teeth of weeding wheel were determined by theoretical analysis. The motion of the weeding wheel was analyzed in the weed-soil and debris-soil models, respectively. Coupled simulation by EDEM and ANSYS was performed to verify the working performance and physical properties of the weeding wheel. Through the field experiments, the optimal working parameters of the machine were 13r/s of weeding wheel speed, 400mm/s of forward speed, and 35mm of weeding depth. With this working parameter, the average removal rate of the weeding machine was 86.7%. It was shown that the design of the weeding machine that separated weeds and soil with combination of throwing and pushing had a good operation quality and met the needs of weeding Radix peucedani in a hilly and mountainous environment with gravelly soil planting environment. The research result can enrich the theoretical basis of the mechanical weeding of Radix peucedani and provide a reference basis for similar studies.