In view of the complexity of design problems, the variety of projects, the difficulty of parameterized deformation design and the high requirements for the professional quality of designers in the design process of combine harvester, appropriate parameterized design methods were sought, and the interactive design system of threshing device was studied based on Skeleton Design. This method only needed to obtain the overall design information of combine harvester equipment, and it can automatically complete the personalized design of combine harvester related parts. Taking the typical component of combine harvester—striprod drum threshing device as the research object, the concepts of Skeleton Design and process body were introduced to realize the personalized. Combined with the overall design process of striprod drum threshing device, the reasoning machine based on rules, examples and models was used to determine the values of design parameters, to establish a threshing device matching relation between structural parameters and working parameters, and then to lay a foundation for the realization of interactive design system. Meanwhile, according to the example tree of threshing device process and Skeleton Design philosophy, the personalized and parameterized design and modeling of threshing drum were completed. Visual Studio was used as the development language, providing technical support for the system, and to achieve interactive design system, and computer aided tridimensional interface application (CATIA) was applied to realize the visualization of this method on the digital interface. The application of SQL database management data realized the objectoriented language environment product design, data sharing and exchange foundation. Taking combine harvester threshing device as the research object, the process of instance design was analyzed, the relationship between instance tree and parameter configuration of threshing device was defined, and the interactive design system was completed through the integration of Skeleton Design, Visual Studio and CAITA secondary development. System test results showed that the system can reduce the specialization of researchers and improve the accuracy of the developed products at the same time, improve the design efficiency, shorten the design cycle, and easy to understand and apply, which can enhance knowledge inheritance and reusability of the model, and make it meet the grain rod roller personalized design requirements, and it can also provide reference for this kind of intelligent design problem. 