The objectives were to investigate the response of yield, grain nitrogen accumulation rate, water use efficiency (WUE) and nitrogen partial factor productivity (PFPN) of spring maize to irrigation and nitrogen, and explore a comprehensive method for evaluating these indexes. The plot experiments were conducted with two factors of irrigation and nitrogen. There were three irrigation levels(W0.6:0.6KcET0;W0.8:0.8KcET0 and W1.0：KcET0, Kc was the crop coefficients, ET0 was the potential reference crops evapotranspiration) and four nitrogen levels (N150: 150kg/hm2;N225: 225kg/hm2;N300: 300kg/hm2 and N375:375kg/hm2). The results showed that the interaction of irrigation and nitrogen application had extremely significant effects on yield, WUE and PFPN, and significant effects on shoot biomass and grain nitrogen accumulation amount. Under the same irrigation levels, the shoot biomass, yield, and WUE were increased at first, and then decreased with the increase of nitrogen application rate. The average correlation coefficient of the principal component analysis, membership function analysis, grey relational grade analysis and the TOPSIS model based on combination weighting was 0.465~0.787, which had a strong correlation. The combined evaluation model based on overall difference showed that W0.8N300 had the highest score. Further comprehensive analysis, considering the uneven distribution of annual rainfall in Ningxia, the results suggested that when the sum of irrigation amount and effective rainfall was 544mm and nitrogen application rate was 260kg/hm2, the evaluations of comprehensive index could reach the maximum. The research provided a guidance for scientific management of water and nitrogen application for spring maize under the local drip fertigated condition in sandy soil area in Ningxia.