Boiler flue gas has become an important source of atmospheric pollution, biomass fuel boiler was applied widely. However, the biomass boiler flue gas purification technology and equipment was shortage. In order to further reduce the pollution of biomass flue gas emissions, a multiple flue gas purification device with dust removal, desulphurization and waste heat utilization was developed. Flue gas dust removal using cyclone separation and atomized spray method, flue gas desulfurization using alkaline water washing and atomized spray desulphurization, waste heat utilization using high, low pressure multistage flue gas heat transfer utilization. The structure design, system calculation and running performance of this biomass flue gas purification device were also studied. The study showed that the flue gas purification device showed a stable operation characteristic and high purification efficiency, which gas temperature, SO2 content, dust content, SO2 removal rate, dust removal rate and other operating parameters were stable during the continuous operation. The result showed that the outlet gas temperature was (62 ± 3)℃, SO2 concentration 4.2mg/m3, and dust content of 4.6mg/m3. The mean SO2 and dust removal rate add up to 70.6% and 90.57% respectively. The multiple flue gas purification device had good operating stability and high dust removal, desulfurization efficiency.