Aiming at the low efficiency of water and fertilizer in winter wheat which caused non-point source pollution in North China Plain, the objective of this experiment was to study the effects of drip fertigation on winter wheat growth, grain yield, water consumption, water use efficiency and nutrient distribution, and provide scientific basis and technical support for the application and extension of drip fertigation. Field experiments were conducted in 2013—2014, 2014—2015 and 2015—2016 three successive winter wheat growing seasons. Under drip fertigation, the fertilizer amount of fertigation was 70% of local fertilizer amount, and the soil matric potential at 0.2m depth for winter wheat was controlled higher than -40kPa. Results showed that under drip fertigation in winter wheat growing seasons in North China Plain, the average yield of winter wheat in 2013—2014, 2014—2015 and 2015—2016 was 7120.5kg/hm2, which was increased by 18.7%. The thousand kernel weight of winter wheat was increased by 4.3g averagely. The average water consumption was 387.9mm. Precipitation was the highest proportion of total water consumption, accounting for 52% in sowing to jointing stage, irrigation was the highest proportion (78%) in jointing to heading stage, while the soil water depletion was the highest (54%) in heading to harvest stage. In three winter wheat growing seasons, the percentage of different water sources in total water consumption showed that irrigation amount was the largest proportion (49%), the soil water consumption and precipitation accounted for 25% and 24%, the groundwater supplementary amount was the lowest, only 2%. Under drip fertigation, water use efficiency and irrigation water use efficiency for winter wheat was 1.8kg/m3 and 3.9kg/m3, which were increased by 38% and 95%, respectively compared with surface irrigation. The nutrient mainly distributed in 0~40cm layers with high nutrient efficiency and low nutrient leaching. In North China Plain, when the fertilizer amount of fertigation was 70% of local fertilizer amount with losscontrol fertilizer as basal fertilizer and drip irrigation, the grain yield was increased by 18.7% with better spike grain number and thousand kernel weight. Meanwhile, drip irrigation can save water by 36% and save fertilizer by 30%, improve irrigation water use efficiency by 95% and increase water use efficiency by 38%.