Complex ecological network is a hotspot in the study of regional eco-environmental sustainability in recent years. The remote sensing image in 2016, DEM data and so on in Dengkou County were used as research material. The concept of ecological Coulomb force was proposed and based on the force-directed algorithm, a multi-scenario simulation model of ecological network was constructed. Furthermore, combining the minimum cumulative resistance surface model, totally 11 scenarios were set up to study the evolution of the present ecological network. The results were shown as follows: based on the current situation of ecological protection mode, the cumulative ecological resistance surface showed that the wolf mountain piedmont and the northeastern margin of the Ulan Buh Desert had great ecological resistance. In contrast, there were significantly more areas with large cumulative ecological resistance values under the economic development model. With (1.0, 0) to (0, 1.0) model conversion, ecological source grid patches gradually disappeared, the skeleton corridor was gradually broken. In the (0, 1.0) mode, the ecological network had been greatly destroyed. Under the present condition, large-scale land economic development would cause great damage to the ecological network. However, in the (0.9, 0.1) mode, although the destruction occurred on the edge of the desert, the ecological network inside the sample circle was expanded. Under the existing natural resources, there was still room for economic development in Dengkou County, but the space was limited. The multi-scenario simulation model proposed was suitable for the evolution analysis of ecological networks.