The simulation of land use change was studied based on multi-agent model. This paper took Yinchuan Plain as a case study and chose the remote sensing images in 2002 and 2014 as data source. Based on the analysis of the land use pattern evolution and its driving actors, three kinds of agents: government, farmers and urban residents were selected as agents. The decision behavior of these three agents were analyzed combined with 5 factors selected from natural factors, social factors and economic factors and behavior rules of multi-agent were built. Finally, the basic data which were processed by ArcGIS, was imported into the model, and the simulation model of land use spatial pattern based on multi-agent model was established. Furthermore, in order to reveal the response relationship between land use pattern evolution and driving force factors, the study simulated land use pattern under three scenarios: natural increase scenario, rapid social economic development scenario, and basic farmland protection scenario. The simulation results can provide decision support for scientific planning and utilization of land in the study area.