Panax notoginseng harvest is waste of time and labor in hilly areas without mechanization, thus a dieselpowered selfpropelled Panax notoginseng harvester was designed, which consisted of mining shovels, scraping soil part, elevator, compacting soil part, collection boxes and other components. Analytical mapping was used to analyze mining shovels, the angle that Panax notoginseng and soil mixture can successfully pass digging shovel blade was determined as 96°. It was obtained from analysis of elevator kinematics that when elevator was inclined 25°, Panax notoginseng harvester and soil mixture had the highest broken rate. The speed of elevators, vibration frequency of vibrating screen sieve and speed of rototiller were taken as experimental factors, and root damage rate and harvesting net rate were used to conduct second rotary orthogonal combination experiment. The results showed that the experimental factors’ influences on indexes from big to small were frequency vibration of shaker, elevating speed and speed of rototiller. When elevating speed was 0.78m/s, vibration frequency of shaker separator was 10Hz, speed of rototiller was 2.5r/s, the root damage rate and harvesting net rate were 1.6% and 96.32%, respectively. The optimal parameters of influential factors were adopted to verify the results. After the test, root damage rate and harvesting net rate were 1.6% and 96.8%，respectively, which was consistent with calculation results and in line with the harvesting index of agronomic requirements. The study provided a reference technology for development of productlevel Panax notoginseng harvester for medicinal material.