Fertigation technology is a combination of irrigation and fertilization which could effectively improve water and fertilizer utilization ratio. It is widely used in the arid and semiarid areas. In order to explore the application effect and economic benefit of fertigation technology on wine grape, three consecutive years study of “Cabernet Sauvignon” were carried out in Helan Mountain foothill of Ningxia. By setting traditional water and fertilizer management as control (CK), drip irrigation + conventional fertilization management (DF) and fertigation technology (FI) treatments, wine grape yield, quality, cost and economic benefit were analyzed. Results showed that fertigation upfront investment was higher than that of traditional water and fertilizer management, and production increase effect was poor, but the quality and price were significantly improved and then the product price was significantly higher than that of traditional planting mode, the irrigation and pesticide use were decreased significantly. Compared with traditional water and fertilizer management, fertigation technology could save water expends by 1853 yuan/hm2 and save labor costs 9585 yuan/hm2, the average annual income reached 43128 yuan/hm2,the ratio of output to input was as high as 2.98. However, the traditional water and fertilizer management annual income was -7192 yuan/hm2, the ratio of output to input was only 0.77. Traditional water and fertilizer management had high cost and low output. Fertigation technology was low cost and high output, which could solve the low grape quality, high labor and low economic benefits problems. By setting fertigation technology on grape wine in Helan Mountain vineyard, it could significantly improve wine grape quality, save cost and increase benefit. It was suitable for widely using in arid and semi arid regions.