Centrifugal pumps are widely used in the solid particles and liquid delivery, a number of areas petrochemical, aerospace, energy, irrigation and the like. When transporting sandy water, its internal wear becomes serious, which affects the life of unit. Therefore, the movement of particles in a centrifugal pump was investigated and the wear characteristics were predicted. Based on the two-phase particle track model and the Tabakoff and Grant erosion model, the simulation of a centrifugal pump was conducted to get the particle track and erosion regulation under different sands or inlet conditions. The result demonstrated that erosion was mostly taken place in hub and pressure side of vane in the impeller compared with shroud and suction side. The particle velocity to pressure side of the vane was increased with the raise of particle diameter, which would lead to dot impact erosion compared with large particles near the inlet side. While the strip scratch erosion was taken place at the press side of the impeller near the outlet when particle diameter was small. Moreover, the position and erosion shape were influenced by particle diameter in significant measure. While the erosion rate density was increased with the increase of concentration and the inlet velocity. Furthermore, the distribution of particle at the inlet also had effect on the erosion state, which meant that with the increase of uniformity of particle in the inlet, the erosion morphology turned into dispersed distribution from continuous sheet.