Through indoor single-line interference infiltration of clean water film hole irrigation and four different clay and sand grades of single-line interference infiltration of muddy water film hole irrigation tests under the same condition, the influence of single-line interference infiltration characteristics of muddy water film hole irrigation under different clay and sand grades was studied, the relationships between single-line interference infiltration of muddy water film hole infiltration volume, single-line interference time, wetting front movement distance and different clay and sand grades were established, the cumulative infiltration volume model and free surface and interference surface wetting front movement distance models for single-line interference infiltration of muddy water film hole per unit area under different clay and sand grades were put forward, and the infiltration reduction feature and influent law of single-line interference infiltration of muddy water film hole irrigation with different clay and sand grades under the relatively same condition of clean water single-line interference infiltration of film hole irrigation were revealed. The results showed that the single-line interference infiltration of muddy water film hole infiltration per unit area of the cumulative infiltration volume was gradually decreased with the increase of physical clay content d0.01 (particle content with diameters less than 0.01mm), the infiltration coefficient K was decreased with the increase of d0.01, and infiltration index α was increased with the increase of d0.01. In the same infiltration time, the vertical and horizontal wetting front movement distances for free surface and interference surface were gradually decreased and the infiltration reduction rate were gradually increased with the increase of physical clay content d0.01.