Using air as the gas source, the regeneration system of exhaust gas recirculation (EGR) cooler was built to do an experimental study at 18℃, 60℃, 90℃, 120℃, 150℃, 200℃ and 300℃, which was based on nonthermal plasma (NTP) injection system. The influence of temperature on regeneration was investigated by measuring the volume fraction of main active substance (O3, NO2) and regeneration products (COx). The results indicate that CO and CO2 can be detected all the time, which means that the EGR cooler can be regenerated by airfed NTP at a wide temperature range of 18~300℃. In the process of regeneration, the volume fractions of O3 and NO2 show drop trends with the increasing temperature, and they are completely consumed when the temperature is 150℃. And the concentration of NOx decreases obviously firstly and then increases slightly with the rising temperature and gets a low level when temperature is above 90℃. Therefore, the temperature should be controlled at 150℃ in consideration of active substance utilization and NOx control. Additionally, little CO is produced, so that C1(the mass of C in CO) in C12 (the mass of C in COx) is less than 1/8. However, much CO2 is generated and remains relatively stable with the regeneration time. Besides, the trend of C2 (the mass of C in CO2) and C12 are almost same, they are all rising firstly and then dropping with the rising temperature, furthermore, they get the peak at 150℃. In total, the efficiency of main active substance which is generated by NTP reactor, is higher, the more carbon deposition is removed and the regenerative effect is more remarkable, when the regeneration temperature is 150℃.