The one-dimensional mass transfer and heat transfer mathematical models were developed by taking mango cells as a basic unit for the effective prediction and process control of osmo-dehydrofreezing. The mass balance equations for the diffusion of different species were established separately for the intracellular and extracellular volumes taking into account the transfer through the cellular membrane and the plasmodesma. Moreover, the model also considered bulk flow of different species in the extracellular volumes. The thermal balance equations for modeling the subsequent freezing step were developed, which included the phase change phenomena. The numerical solutions were solved by a finite difference method with Matlab programs. A good agreement was obtained between the simulated and experimental results including water loss and solid gain during osmotic dehydration and temperature profile during freezing, and the relative error was controlled in 15%, which proved that this model was practical. Numerical results could describe the distribution of water and sucrose in the intracellular and extracellular volumes of mangoes during osmotic dehydration and show the change of temperature at different time during freezing.