An automatic matching approach of locator scheme was suggested on the basis of fixture cases. Firstly, in light of the number of locating points, the processing information matching index of locating reference was proposed. Secondly, according of the geometrical and topological relation, the geometrical information matching matrix of workpiece was proposed from three levels of point, line and surface. And then, the fitness index of workpiece and corresponding weight were constructed. Thirdly, the decision function of locator scheme was formulated with combination of the processing information matching index. Finally, some typical examples were used to illustrate the proposed automatic matching approach of locator scheme in detail.