Based on the furrow irrigation which was conducted in Yangling District with the clay loam and sandy loam, effects of different combinations of soil infiltration characteristics and Manning roughness on the water advance trajectory and irrigation performance were analyzed. The results show that the spatial variability of soil infiltration characteristics has a great effect on the water advance trajectory and irrigation performance. When optimizing the design of the furrow irrigation, the spatial variability of soil infiltration characteristics must be taken into consideration. However, the spatial variability of Manning roughness affects slightly on the water advance trajectory and irrigation performance. When optimizing the design of the furrow irrigation, the average value of Manning roughness can be used in various irrigation ditches. Based on the above results and verified field experiments, the results show that the average relative error between the measured and simulated values of the water advance trajectory is 7.28%, and the application efficiency, distribution uniformity and storage efficiency between the measured and simulated values are 5.74%, 6.18% and 4.07%, respectively.