A new inverse method for centrifugal pump blade based on free-form deformation, which is used to parametric control of the pump blade shape, was proposed. The blade was implanted to a trivariate control volume which is equally subdivided by control lattices. The control volume can be deformed by moving the control lattices in it, thereupon the object is deformed. The parametric method for the blade shape according to the distribution of the blade load was proposed, and the lattices deformation function was constructed. The deformation of the lattices was implemented according to the three dimensional turbulent flow solve in pump and the desired load distribution of blade. At last, the blade shape was controlled by the physical parameters. The calculation case shows that the proposed inverse method based on FFD method is rational.