In order to design the high-oxygen modified atmosphere packaging in mushroom (Agaricus bisporus), Weibull model and Logistic model were applied to study in-package O2 and CO2 concentration and predict the respiration of mushroom. The results showed that O2 concentration in high oxygen package decreased from initial 80kPa to 50kPa after 50h, while it declined slowly in control. The CO2 concentration under both treatments increased gradually, and it reached the maximum value at the end of storage. The predicted concentration of O2 and CO2 fitted well with the experimental value. The respiration of mushroom under high oxygen was well described by the CO2 production rate.