In order to improve the reliability of the whole circulation process about pork product, GO methodology was applied in the reliability research. First, the structure model of the whole circulation process about pork product was built up, and the influencing factors of each step, including pig-breeding, slaughter-process, storage-transportation and sales, were diagnosed. Secondly, with the GO methodology the whole circulation process about pork product was transformed into the GO chart, and then the failure probability of influencing factors were determined by the method of frequency statistics and fuzzy analytic hierarchy process and the process reliability was calculated in detail. Finally, reliability of the whole circulation process about pork product was analyzed qualitatively and the importance degree of minimal cut sets was calculated so that the main factors influenced the reliability of whole circulation process about pork product were determined. The quantative and qualitative methods were compared and the result showed that the GO method had effectiveness and superior performance in research on reliability of the whole circulation process about pork product. 