Using indoor experimental tanks, a simulated rainfall experiment was conducted to explore the effect of soil macropore on slope Br- loss. Results revealed that the total amount and average rate of Br- loss over slope land with soil macropore were less than those without soil macropore. A model of solute loss on slope was built based on fuzzy neural network. The characteristic scale of macropore, rainfall intensity, rainfall duration and adsorption coefficient of ions were used as input variables and the cumulative solute loss quantity on slope was output. Comparing with 160 sets of measured data, simulation results reflected real cumulative solute loss quantity on slope, which showed the established model was effective. 