According to the current problem of materials’singleness and biogas slurry and residue handling difficultly in large and medium-sized biogas engineering, wet and dry coupling anaerobic fermentation combined with dry and wet fermentation was put forward, namely wet fermentation used livestock and poultry manure as raw materials, and dry fermentation used mixture of straw and biogas slurry and residue from wet fermentation as fermentation substrate. The effect of wet and dry coupling ratio-biogas residue straw ratio and leachate recirculation on fermentation properties were studied, and the results show that with the increase of BRSR, start time is shorten and the biogas production increases. TS of leachate from dry fermentation is below 1%, achieves the effect of the solid-liquid separation, is conducive to leachate recycling and spraying, solves the difficult problem of biogas slurry and residue treatment from wet anaerobic fermentation, and realizes the cyclic utilization of biogas slurry.