An air-velocity distribution model of greenhouse air-assisted sprayer was built by means of CFD simulation technique. Experiments were designed for the evaluation of the simulation results. The research showed that the air velocity decreased as the distance increasing from spray nozzle in vertical and horizontal directions. The change of air flow rate at nozzle had no remarkable influence on the characteristic of air-velocity distribution, but enlarged the droplet distribution area significantly. By increasing the nozzle flow rate from 25 m/s to 50 m/s, the blowing distance could be increased from 2.4 m to 3.6 m, the range of air-velocity distribution expanded from 0.20 m to 0.25 m. The contrast of experiment results and simulation results showed that the simulation model built can be an accurate simulation of the air-velocity distribution of a greenhouse air-assisted sprayer.