To construct the spatial cam parametric feature model efficiently and accurately, discrete point cloud data were obtained by profile equation of spatial cam. Non-uniform rational B-splines (NURBS) was adopted to reconstruct the profile of spatial cam. Based on the parametric feature model, the spatial cam indexing mechanism was set up to perform kinematics simulation, and then the manufacturing model was generated to simulate the spatial cam NC machining. Finally, the spatial cam was machined on four-axis CNC machining center by NURBS interpolation method. The results showed the follower motion curves (the maximum velocity and acceleration) were smoother than modified-sine curves. The profile machining error related to the processing route curvature, the maximum was not more than 0.01mm and located in the maximum of the absolute curvature. Profile reconstruction based on NURBS was liable and effective for design and machining of spatial cam. 