Reconfigurable manufacturing process design was combined with characteristics of reconfigurable machine tools. Beginning with the proposed process unit and process section, the processing information matrix was built through the processing information formulation. Then the processing unit was established and the division method of process section was proposed. Through the cross two way method, a variety of process schemes which meet the reconfigurable manufacturing requirements were obtained. Based on the similarity judgment model of processing plan, the reasonable processing schemes for the reconfiguration of reconfigurable machine tools were found out, which provided scientific basis for realizing the manufacturing flexibility in part family. Finally, an example of processing design for the cylinder front covers family was given to verify the validity of the proposed processing method.