The microwave-vacuum drying characteristics of litchi pulp were studied and the effects of microwave power, relative pressure and loading capacity on drying rate of litchi pulp were investigated. The results showed that the drying rates of litchi pulp were markedly affected by microwave power and loading capacity, whereas, there was no obviously affected by relative pressure. The experimental drying data of litchi pulp were used to fit twelve available drying models, and coefficients of models were determined by non-linear regression analysis. It showed that Modified Henderson and Pabis model had higher correction coefficient R2, lower square sum of error (SSE) value and root mean square error (RMSE) value and could exactly describe and predict the moisture dynamics of litchi pulp during microwave-vacuum drying process.