A linear 2-DOF model of steering for the four-wheel drive high clearance spray chassis was established. Taking front-wheel turning for example, the actual steering angle was calculated. A steering anti-slip control system by using absolute difference of the actual speed ratio and theoretical speed ratio as control object was designed. The device of steering anti-slip electro-hydraulic system was constructed and by experiment the designed system was verified when the turning angel were at 5°,10°,15°,20°,25°,30° respectively and turning angle changed in continuous between 0°～30°. The results show that the turning anti-slip control effect for four-wheel drive high clearance sprayer is excellent, the maximum control error is 2.01% and the average value is 1.25%.