In order to avoid the disadvantages of cumbersome, error-prone, long cycle of shaft strength calculation by traditional method, a multi-stage centrifugal pump shaft strength calculation program was developed based on parametric design language APDL. By transferring script file of the self model program and executing the command SOLVE to calculate, parametric automatic modeling, load application and solution, and the results of 3-D parametric display under zero-flow conditions and design point conditions were realized. The stress distribution of the shaft at different conditions on different sections and dangerous position were clearly described, and the accurate calculation of the shaft strength can be performed. Application examples showed that the design and development application program was used friendly and can get accurate calculations with visual results. This program of shaft strength calculation greatly improved the computational efficiency of shaft strength and reduced the analysis cost.