Three degree of freedom hybrid vibration screen was designed to sort granular material based on the theory of parallel mechanism. The vibration screen composited of screen box, vibration motor, motor fixed seat, spring, angle adjusting device, support frame, longitudinal vibration chain, transverse vibration chain and base. The support and excitation function of screen box was separated. The support of screen box was suspension support. The main excitation mechanism was complete decoupling hybrid mechanism 2PRRR—P(2R) which could realize the three dimensional vibration of X, Y and Z of the screen box. Test results showed that the three dimensional vibration of X, Y and Z of the screen box improved the performance of dispersion function by 33.23% on average and the function of leaking screen by 73.55% on average. This vibration screen has the good adaptability to various materials.