Automated mechanical transmission (AMT) control system for heavy vehicle was developed based on dSPACE control. Hardware development, automatic code generation, vehicle calibration and testing were carried out based on V-type development process. Hydraulic control system, gear shifting actuator and clutch automatic control system for AMT were designed. The control strategy was confirmed. The development of control software was accomplished. Vehicles calibration and control performance testing based on the 12-gear MT of heavy truck platform were performed. The results showed that the heavy vehicle AMT based on the dSPACE achieved the expected goal. The software development and vehicle parameters calibration could be controlled. Thus, the repeated work could be diminished in design, development and the process of testing to typing, so that the development cycle could be accelerated.