A model of laser milling on Al2O3 eramic was established based on ANSYS finite element software. Laser milling process was analyzed by APDL code, and the dynamic distribution of the temperature field during the milling process was studied. The influence of the laser power and scanning velocity on the milling width and depth were investigated. According to the numerical simulation, the relevant parameters were used in the laser milling experiment. It indicated that the numerical simulation results were consistent with the experiment, the effect of laser milling on Al2O3 ceramic could be accurately predicted by the established model. The width and depth of laser milling were increased by laser power and decreased by the scanning velocity. Compared with the scanning velocity, laser power had more important influence on laser milling.